Chronic kidney disease (CKD) is now considered one of the strongest risk factors for the morbidity and mortality in obese patients (1). Particularly in patients with CKD, a common diabetic complication, systemic inflammation is associated with adverse outcomes including poor quality of life and increased mortality (2). Inflammasome activation is involved in the onset of kidney disease and specifically, the inflammasome-IL-1a/IL-ß-IL-1R system is a central element of kidney inflammation and the systemic complications (3). Regular physical activity benefits cardiometabolic, neuromuscular and cognitive function across all stages of CKD and provides an approach to address the multimorbidity of the CKD population. More importantly, it has been shown that improving muscle health is associated with renoprotective effects (4).
1. Câmara NO. et al, Nat Rev Nephrol. 2017 Mar;13(3):181-190. www.nature.com/articles/nrneph.2016.191
2. Cobo G. et al, Nephrol Dial Transplant. 2018 Oct 1;33(suppl_3):iii35-iii40.
5. Gaith MM. et al, Methods Mol Biol. 2018;1714:57-66. link.springer.com/protocol/10.1007%2F978-1-4939-7519-8_4 6. Latz E. et al, Semin Immunol. 2018 Dec;40:61-73.
7. Niu L. et al, Mol Syst Biol. 2019 Mar 1;15(3):e8793. msb.embopress.org/content/msb/15/3/e8793.full.pdf