We are interested in understanding the mechanisms underlying the central role of adipose tissue in maintaining, restoring but also deteriorating whole body insulin sensitivity, as the first and most important step regulating the transition from “healthy” obesity towards type 2 diabetes and the metabolic syndrome. In this context, we are especially interested in understanding cellular heterogeneity and the role of individual adipocyte lineages during development, weight gain and disease. Using a combination of mouse genetics, molecular and cell biology as well as state of the art whole tissue imaging and sequencing technologies, we study the role of cell surface proteins in integrating various extracellular and environmental signals to mediate specific cellular responses.
Unraveling Key Regulators Defining Adipose Tissue as Central Regulator of Metabolism
To further strengthen our team, we are looking for a highly motivated, creative thinking candidate with a strong interest in unraveling the complexity of adipose tissue. Potential projects include studying adipocyte/ neuron interactions, the impact of gut microbiota derived metabolites on adipose tissue as well as establishing and utilizing novel mouse lines studying the spatial and temporal distribution of insulin action in vivo.
Schoettl T, Fischer IP, Ussar S, (2018) Heterogeneity of adipose tissue in development and metabolic function, Journal of Experimental Biology, DOI: 10.1242/jeb.162958
Fischer IP, Irmler M, Meyer CW, Sachs SJ, Neff F, Hrabe de Angelis M, Beckers J, Tschop MH, Hofmann SM, Ussar S, (2018) A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue, International Journal of Obesity, doi: 10.1038/ijo.2017.224
Pramme-Steinwachs I, Jastroch M, Ussar S, (2017) Extracellular calcium modulates brown adipocyte differentiation and identity Scientific Reports, 7(1):8888
Ussar S*, Haering MF*, Fujisaka S, Lutter D, Lee KY, Li N, Gerber GK, Gry L, Kahn CR, (2017) Regulation of glucose uptake and enteroendocrine function by the intestinal epithelial insulin receptor Diabetes, 66(4):886-896 (* equal contribution)
Fujisaka S, Ussar S, Clish C, Devkota S, Dreyfuss J, Sakaguchi M, Soto M, Konishi M, Sotic S, Altindis E, Li N, Gerber G, Bry L, Kahn CR, (2016) Antibiotic effects on gut microbiota and metabolism are host dependent Journal of Clinical Investigation, 126(12):4430-4443
Ussar S*, Griffin NW*, Bezy O*, Fujisaka S, Vienberg S, Softic S, Deng L, Bry L, Gordon JI, Kahn CR, (2015) Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome Cell Metabolism, 22(3):516-30 * co-first author
Ussar S, Lee K, Dankel SN, Boucher J, Haering MF, Kleinridders A, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR (2014) Asc-1, PAT2 and P2RX5 are novel cell surface markers for white, beige and brown adipocytes, Sci. Transl. Med.,6(247):247ra103
Ussar S, Bezy O, Bluher M, Kahn CR (2012) Glypican-4 Enhances Insulin Signaling Via Interaction with the Insulin Receptor and Serves as a Novel Adipokine, Diabetes 61(9):2289-98